What's President Eisenhower Have To Do Blood Clots?
In the 1920's North Dakota farmers noticed
their herds were mysteriously dying from internal bleeding after eating moldy sweet clover hay. This led scientist Karl Paul Link and his team at the University of Wisconsin to investigate, eventually identifying the compound dicoumarol as the cause in 1933. From this discovery, Link developed a more potent version called warfarin (named after the Wisconsin Alumni Research Foundation) in 1948, which was initially marketed as an effective rat poison.
The transition from poison to medicine came after a Navy recruit survived a warfarin suicide attempt through vitamin K treatment, demonstrating its potential for controlled medical use. Warfarin was approved for human use in 1954, with President Eisenhower becoming one of its most famous early patients. Its predictable effects, the availability of vitamin K as an antidote, and the ability to monitor its impact through blood tests made it a revolutionary treatment for preventing blood clots, and although its use is being replaced with newer agents it remains widely used today.
Welcome to the 90th edition of ResusNation!
What's The Peak & Plateau?
Ever get confused about ventilator pressures? This week I broke down the difference between peak and plateau pressures in a way that finally makes sense! Think of peak pressure as the whole picture - it shows both how hard it is for air to move through the breathing tubes AND how stiff the lungs are. But here's the trick: when you hear the peak pressure is high, you've got to ask about the plateau pressure too. It's like hitting pause on the ventilator to see what's really going on with the lungs themselves.
If both pressures are high, you're probably dealing with stiff lungs, but if only the peak is high, you might just have a blocked or kinked tube. Pretty useful stuff to know when you're trying to figure out what's wrong! Check out the full video [here] to get all the details.
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Status Epilepticus
In this episode, Dr. Danya Khoujah delivers an in-depth guide to managing status epilepticus, recorded live at ResusX: ReUnion. She covers the critical first steps of treatment with benzodiazepines, the importance of dosing correctly, and the selection of second-tier antiepileptic medications. Dr. Khoujah emphasizes having a clear algorithm for refractory cases and highlights the need for continuous EEG monitoring to diagnose subtle seizures. Tune in to learn how to optimize your approach to one of the most high-stakes scenarios in emergency medicine!
Check out this video now and watch the entire ResusX: ReUnion conference for more content from Danya and our other all-star faculty!
ResusX:Volume 3 Is Coming this Week!
Ever wished you could have the brightest minds in emergency medicine right in your pocket? Well, this week you'll get your chance! We're thrilled to announce exclusive access to ResusX's most watched talks from past conferences.
Imagine having Scott Weingart teach you the secrets of monitor mastery, or learning about post-arrest ECGs from the legendary Amal Mattu. Want to know when to rush your cardiac arrest patient to the cath lab? Dr. Hedayati has got you covered.
đ± Watch 25 HD videos anytime, anywhere with our mobile player
đĄ Master critical topics from post-arrest care to managing the crashing cirrhotic
âïž Learn from the absolute rockstars of resuscitation medicine
đ° Special discount for residents, nurses, NPs, PAs, and paramedics
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Stay tuned for our full announcement this week! Have questions? Drop a line to [email protected].
P.S. These aren't just lectures â they're your playbook for managing your sickest patients. Don't miss out!
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Headache Zebras
What if your patientâs headache isnât just âanother migraineâ? In this fascinating lecture from ResusEM7 (see the link below for more lectures), Dr. Abby Bierowski reveals three rare but critical headache syndromes, or âzebras,â that every emergency professional should recognize.
She guides you through cases of pituitary apoplexy, reversible cerebral vasoconstriction syndrome (RCVS), and Alice in Wonderland syndrome, sharing practical tips to identify and manage these unique conditions. If youâre ready to think beyond the usual suspects, this video is a must-watch!
Check out this video now and watch the entire ResusEM7 conference for more content from Abby and our other all-star faculty!
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